|
Symbol Name ID |
Fli1
Friend leukemia integration 1 MGI:95554 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Epistaxis |
Joint hemorrhage |
Persistent bleeding after trauma |
Bruising susceptibility |
Petechiae |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
| Disease(s) Associated with FLI1 | |||||||||||||||||||
| thrombocytopenia |
| Mouse Phenotypes | hematopoietic system phenotype |
abnormal megakaryocyte differentiation |
decreased B cell proliferation |
decreased thymocyte number |
increased thymocyte number |
enlarged spleen |
spleen hyperplasia |
abnormal erythropoiesis |
abnormal B cell differentiation |
abnormal class switch recombination |
increased transitional stage B cell number |
abnormal thrombopoiesis |
anemia |
impaired hematopoiesis |
abnormal megakaryocyte morphology |
decreased megakaryocyte cell number |
increased erythroid progenitor cell number |
abnormal megakaryocyte progenitor cell morphology |
abnormal proerythroblast morphology |
increased erythrocyte cell number |
decreased hematocrit |
decreased granulocyte number |
thrombocytopenia |
decreased follicular B cell number |
increased marginal zone B cell number |
decreased B cell number |
increased NK cell number |
increased monocyte cell number |
abnormal leukocyte morphology |
abnormal splenic cell ratio |
decreased IgG1 level |
decreased IgG3 level |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
| Fli1tm1.1Dkw/Fli1tm1.1Dkw | |||||||||||||||||||||||||||||||||
| Fli1tm1Adh/Fli1tm1Adh | |||||||||||||||||||||||||||||||||
| Fli1tm1Ber/Fli1tm1Ber | |||||||||||||||||||||||||||||||||
| Fli1tm1Dkw/Fli1tm1Dkw | |||||||||||||||||||||||||||||||||
| Fli1tm1.1Dkw/Fli1+ | |||||||||||||||||||||||||||||||||
| Tg(Fli1)1Ber/0 | |||||||||||||||||||||||||||||||||
| Fli1tm1Morl/Fli1tm1Morl Tg(Mx1-cre)1Cgn/0 (conditional) |
* | ||||||||||||||||||||||||||||||||
| Fli1tm1Morl/Fli1tm1.1Morl Tg(Mx1-cre)1Cgn/0 (conditional) |
* | ||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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